这有可能逆转疟疾控制所取得的成果
Vassilis Douris， Gareth Lycett，蚊帐施加的强烈选择压力已经在非洲按蚊种群中引发了对拟除虫菊酯的广泛且不断升级的抗药性，自本世纪初以来，该蛋白富含于腿部， 附：英文原文 Title: A sensory appendage protein protects malaria vectors from pyrethroids Author: Victoria A. Ingham， 研究人员表示，SAP2沉默完全恢复了蚊子的死亡率，这可能是由于SAP2与拟除虫菊酯类杀虫剂的高亲和力结合所致， Marion Morris。
含有拟除虫菊酯的蚊帐大大降低了非洲与疟疾有关的发病率和死亡率， threatening to reverse the gains that been made by malaria control2. Here we show that expression of a sensory appendage protein (SAP2)，这一研究成果于2019年12月25日在线发表在国际学术期刊《自然》上， whereas SAP2 overexpression results in increased resistance。
probably owing to high-affinity binding of SAP2 to pyrethroid insecticides. Mining of genome sequence data reveals a selective sweep near the SAP2 locus in the mosquito populations of three West African countries (Cameroon， which is enriched in the legs，而SAP2过表达导致抗药性增加， Nicholas J. Harding， Hilary Ranson IssueVolume: 2019-12-25 Abstract:Pyrethroid-impregnated bed nets have driven considerable reductions in malaria-associated morbidity and mortality in Africa since the beginning of the century1. The intense selection pressure exerted by bed nets has precipitated widespread and escalating resistance to pyrethroids in African Anopheles populations，这反映了在布基纳法索报道的蚊子对拟除虫菊酯抗性增强 ， 研究人员发现了一种感觉性附肢蛋白（SAP2）的表达，隶属于施普林格自然出版集团，并且在蚊子与拟除虫菊酯接触后进一步被诱导。
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赋予拟除虫菊酯对冈比亚按蚊的抗性， John Vontas， Amalia Anthousi，这有可能逆转疟疾控制所取得的成果，。
并且观察到与单体型相关的单核苷酸多态性增加。
confers pyrethroid resistance to Anopheles gambiae. Expression of SAP2 is increased in insecticide-resistant populations and is further induced after the mosquito comes into contact with pyrethroids. SAP2 silencing fully restores mortality of the mosquitoes，SAP2的表达在抗药性种群中增加， Guinea and Burkina Faso) with the observed increase in haplotype-associated single-nucleotide polymorphisms mirroring the increasing resistance of mosquitoes to pyrethroids reported in Burkina Faso. Our study identifies a previously undescribed mechanism of insecticide resistance that is likely to be highly relevant to malaria control efforts. DOI: 10.1038/s41586-019-1864-1 Source: https://www.nature.com/articles/s41586-019-1864-1 期刊信息 Nature： 《自然》，这项研究确定了以前未知的抗药性机制，一种感觉附肢蛋白能够保护疟疾病媒免受拟除虫菊酯的杀伤，其可能与控制疟疾高度相关， 基因组序列数据的挖掘揭示了在三个西非国家（喀麦隆、几内亚和布基纳法索）的蚊子种群中SAP2基因座附近的选择性清除，创刊于1869年， 本期文章：《自然》：Online/在线发表 英国利物浦热带医学院Hilary Ranson、Victoria A. Ingham等研究人员合作发现。