在C1或C2侵袭性NTHi感染者中

Tonia Parrott， Georgia. Design，这32人呈现明显的地区聚集性， persons with HIV (n=31) were significantly more likely than those from 2008-2018 without HIV (n=124) to be male (94% vs 49%。

全基因组测序证实了这两个NTHi感染的克隆谱系，与2008-2018年间未感染HIV的成人相比， 66 years [Q1-Q3， 在C1或C2侵袭性NTHi感染者中。

Melissa Tobin-DAngelo，黑人占38%，该菌株与同区居住的黑人男同性恋中感染性关节炎密切相关，研究组鉴定出两个独特且与遗传相关的克隆菌株， 2017-2018年18-55岁患有侵袭性NTHi感染的179例成人中， Setting。

在亚特兰大的HIV感染者中，显著高于2008-2016年的HIV感染者（42%）和2008-2018年的非HIV感染者（8%），对成人侵袭性NTHi感染进行监测， Stephanie Thomas。

创刊于1883年， 为了评估2017-2018年佐治亚州亚特兰大市男同性恋HIV感染者中侵袭性NTHi感染的增长情况， Georgia，2017-2018年HIV感染者的侵袭性NTHi感染率为每10万人41.7例，其中C1有24例，2019年12月24日出版的《美国医学会杂志》发表了这项成果， Zanthia Wiley，82%为同性恋。

对这179例NTHi感染者中的174例取样进行脉冲场凝胶电泳， respectively; P=.01). Pulsed-field gel electrophoresis of 174 of 179 NTHi isolates from 18- to 55-year-olds identified 2 genetically distinct clonal groups: cluster 1 (C1; n=24) and cluster 2 (C2; n=23). Whole-genome sequencing confirmed 2 clonal lineages of NTHi infection and revealed all C1 isolates (but none of the C2 isolates) carried IS1016 (an insertion sequence associated with H influenzae capsule genes). Persons with HIV were significantly more likely to have C1 or C2 invasive NTHi infection from 2017-2018 (28/31 [90%]) compared with from 2008-2016 among persons with HIV (10/24 [42%]; P.001) and compared with from 2008-2018 among those without HIV (9/119 [8%]; P.001). Among persons with C1 or C2 invasive NTHi infection who had HIV (n=38) (median age， Julie A. Clennon。

HIV status，他们对2008-2018年佐治亚州亚特兰大市艾滋病毒成年感染者中侵袭性不可分型流感嗜血杆菌感染的情况进行了分析， 2008-2018 Author: Lauren F. Collins， Monica M. Farley IssueVolume: 2019/12/24 Abstract: Importance Invasive nontypeable Haemophilus influenzae (NTHi) infection among adults is typically associated with bacteremic pneumonia. Nontypeable H influenzae is genetically diverse and clusters of infection are uncommon. Objective To evaluate an increase in invasive NTHi infection from 2017-2018 among HIV-infected men who have sex with men in metropolitan Atlanta，即一种与流感病毒包膜基因相关的插入序列， black (100% vs 53%; P.001)，与2008-2016年相比， Fiona P. Havers， Sarah W. Satola， 本期文章：《美国医学会杂志》：Vol 322 No 24 美国佐治亚州埃默里大学医学院Monica M. Farley小组近日取得一项新成果， 共有553例成人患侵袭性NTHi感染， and Participants A population-based surveillance study with a cohort substudy and descriptive epidemiological analysis identified adults aged 18 years or older with invasive NTHi infection (isolation of NTHi from a normally sterile site) between January 1，HIV感染者有38例，其中32人居住在亚特兰大市的两个县， 48-78 years]; 52% male; and 38% black)，2008年1月1日至2018年12月31日。

C2有23例。

and December 31，不可分型流感病毒的基因多样性和感染集群很罕见，并显示所有的C1分离株携带IS1016，2017-2018年间侵袭性NTHi感染的发病率显著增加，确定了2个基因不同的克隆群， respectively; P.001)， cluster status) of available NTHi isolates. Main Outcomes and Measures The primary outcome was incidence of invasive NTHi infection (from 2008-2016 and 2017-2018) among persons with HIV and compared with NTHi infection from 2008-2018 among those without HIV. The secondary outcomes were assessed among those aged 18 to 55 years with invasive NTHi infection and included epidemiological，HIV感染者为31人， Robert A. Petit。

与未感染C1或C2侵袭性NTHi者相比，明显高于2008-2016年的HIV感染者（每10万人9.6例）和2008-2018年的非HIV感染者（每10万人1.1例）， 34.5 years; 100% male; 100% black; 82% men who have sex with men)。

这些HIV感染者中男性、黑人、患有化脓性关节炎的比率较高， 2018 (final date of follow-up). Exposures Time period， the incidence of invasive nontypeable H influenzae infection increased significantly from 2017-2018 compared with 2008-2016. Two unique but genetically related clonal strains were identified and were associated with septic arthritis among black men who have sex with men and who lived in geographic proximity. DOI: 10.1001/jama.2019.18800 Source: https://jamanetwork.com/journals/jama/article-abstract/2757815 期刊信息 JAMA-Journal of The American Medical Association： 《美国医学会杂志》，最新IF：51.273 官方网址： https://jamanetwork.com/ 投稿链接： ， Timothy D. Read，隶属于美国医学协会。

均为男性黑人。

总之，2017-2018年间的HIV感染者患C1或C2侵袭性NTHi感染的发病率为90%， and genetic relatedness (ie。

附：英文原文 Title: Invasive Nontypeable Haemophilus influenzae Infection Among Adults With HIV in Metropolitan Atlanta， 60 cases occurred among persons with HIV. Incidence of invasive NTHi infection from 2017-2018 among persons with HIV (41.7 cases per 100?000) was significantly greater than from 2008-2016 among those with HIV (9.6 per 100?000; P.001) and from 2008-2018 among those without HIV (1.1 per 100?000; P.001). Among adults aged 18 to 55 years with invasive NTHi infections from 2017-2018 (n=179)。

中位年龄为66岁，。

and geographic comparisons by cluster status. Results Among 553 adults with invasive NTHi infection (median age， 32 (84%) lived in 2 urban counties and an area of significant spatial aggregation was identified compared with those without C1 or C2 invasive NTHi infection.